Not a dermatologist, but running a medical aesthetics clinic means I hear about skin reactions constantly -- and unwashed clothing comes up more than most people expect, especially around the face and neck where patients notice irritation between treatments. The chemical load I hear most complaints about isn't random contamination -- it's the finish treatments intentionally applied to fabric. Wrinkle-resistant finishes (formaldehyde-releasing compounds) and optical brighteners are the ones that show up repeatedly in conversations with our providers, particularly when patients come in wondering why their skin flared after a new shirt or collar. From what I see clinically, rough or synthetic-blend fabrics worn at friction points -- collar lines, waistbands, bra straps -- are where people first notice it. Kids are genuinely more reactive; parents bring children in with rashes that trace directly back to new school clothes worn without washing. Wash new clothes before wearing them. That's the consistent recommendation from every provider on our team. One wash cycle dramatically reduces the chemical load, and for kids or anyone with barrier-compromised skin, it's non-negotiable.