I've worked with muscle markers like myostatin and creatine kinase. Tracking these showed us exactly what was happening during weight loss, especially with GLP-1s. It was tricky to monitor exercise mimetics at first, but it helped us see how people recover. If I were designing these trials, I would track muscle strength and signaling over time, not just fat loss. People want to stay strong, not just see a lower number on the scale. If you have any questions, feel free to reach out to my personal email