Coenzyme Q10 (CoQ10) is not only involved in energy production in mitochondria, but it is also a potent antioxidant, and studies have demonstrated its most effective benefits to the heart, specifically, enhancing the symptoms of heart failure, blood pressure in statins and to the advantage of patients using statins. Both versions, ubiquinone and ubiquinol, are effective because the body can convert them on demand; however, absorption is more of a formulation and timing issue. Taking 100200mg/day in soft-gel or solubilized form is more bioavailable. Although safe and well tolerated, CoQ10 can potentially diminish warfarin effect, and can interact additively with blood pressure or diabetes medications, making monitoring recommended. There is current evidence to back its utilization as an adjunct to cardiovascular health and migraine prevention, but it has been less convincing regarding increases in general energy or anti-aging. In general, CoQ10 can be a useful supplement in the case of sufficient use and with the supervision of a health professional, but it cannot substitute regular medical treatment.