The most stressful aspect of the grant hamster wheel, aside from a decline, is the paperwork involved in submission, particularly for the large joint proposals that have become a common exercise. This ranges from tight budgeting, in which operating costs and overhead leave little flexibility for discovery and growth, to concern about supporting grad students and postdocs, to the madness of getting all of your collaborators to properly submit their own paperwork. I deal with this stress by distancing myself. It is the same as when we do anything that is meant to bring about good, but has unknown or low odds of moving the needle very far. You just accept that good work takes many tries. As in a basketball game, you may miss a few hoops but it's the score at the end of the game that matters. Plus there are many games in one's season of life!